This is a recurring or persistent localization of dermatitis to the wrists, palms, or fingers of the hand, or the soles of the feet. It can be exacerbated by contact with offending allergens, e.g., soaps, solvents, or metals for the hands, dyes for the feet. It is usually associated with atopy and xerosis. One form, called "winter feet," usually affects older children and has a clinical picture of painful, mildly erythematous, dry scaling and fissuring of the sole, particularly the toes and ball, of the foot.

7. Nipple eczema

When seen in AD patients, this is usually a chronic bilateral condition characterized by a moist patch of dermatitis localized to the nipple and areola area. It responds to glucocorticoid treatment. It is important because the appearance can mimic Paget's disease of the nipple, a serious condition which is usually unilateral and associated with a small but chronic discharge, and indicative of an underlying ductal carcinoma of the mammary gland. Paget's does not respond to corticosteroid therapy.

8. Conjunctivitis

The recurring irritation seen in the skin is often reflected in the eyes.